In our latest video, Dr. Eric Kunkel, Senior VP of Research and Development at MedCision, walks viewers through the validation and performance characteristics of ThawSTAR® Automated Cell Thawing System.
Dr. Kunkel has an extensive background in cell biology, as well as drug discovery and development. His experience has led to personal appreciation for the importance of standardization and reproducibility when handling cells. The ThawSTAR system standardizes one of the most important steps of cryopreservation-transitioning cells from a deep frozen state back to a viable state. Dr. Kunkel discusses how ThawSTAR compares to other dry heating methods.
“Rapid thawing of frozen cell samples is shown to improve viability and recovery of many cell types Compared to other dry heating methods, thawing in a ThawSTAR system is more rapid due to the efficient coupling of the heating elements to the vial.” ThawSTAR can thaw samples 2-3 times faster than a heating block or bead bath. Its function, designed to mimic the thawing profile of a 37oC water bath, incorporates no liquids that can carry contamination and risk the integrity of the sample.
Reproducibility is also engineered into the system. As Dr. Kunkel explains, the system has a number of redundant safety features incorporated into its design. “ThawSTAR units have built in self checks and control mechanisms to ensure they are performing properly on start-up and in ready mode. These firmware routines contribute to the reproducible thawing profile of the instrument unit-to-unit and day-to day.” ThawSTAR also features built in audio and visual indicators that let you know when each thaw cycle is finished. MedCision recommends using ThawSTAR in conjunction with the ThawSTAR CFT Transporter, which prevents unwanted freeze-thaw cycles during transport of cell vials from liquid nitrogen.
The video goes on to describe important validation data that help highlight the system’s unique capabilities and function. Dr. Kunkel finishes his presentation on a high note: “The ThawSTAR automated cell thawing system is a significant improvement over traditional thawing methods, and will be a welcome addition to your cell culture workflow.”